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- Wiley
More About This Title Novartis Foundation Symposium 283 - VascularDevelopment
English
In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups.
The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues.
The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation.
While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues.
With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
English
English
Christer Betsholtz Chair’s introduction 1
Maria Grazia Lampugnani and Elisabetta Dejana The control of endothelial cell functions by adherens junctions 4
Discussion 13
Maike Schmidt, Ann De Mazière, Tanya Smyczek, Alane Gray, Leon Parker, Ellen Filvaroff, Dorothy French, Suzanne van Dijk, Judith Klumperman and Weilan Ye The role of Egfl 7 in vascular morphogenesis 18
Discussion 28
Max Levin, Andrew J. Ewald, Martin McMahon, Zena Werb and Keith Mostov A model of intussusceptive angiogenesis 37
Discussion 42
Tomáš Kucera, Jan Eglinger, Boris Strilic and Eckhard Lammert
Vascular lumen formation from a cell biological perspective 46
Discussion 56
Christopher J. Drake, Paul A. Fleming and W. Scott Argraves
The genetics of vasculogenesis 61
Discussion 71
Steven Suchting, Catarina Freitas, Ferdinand le Noble, Rui Benedito, Christiane Bréant, Antonio Duarte and Anne Eichmann Negative regulators of vessel patterning 77
Discussion 80
Taija Mäkinen and Kari Alitalo Lymphangiogenesis in development and disease 87
Discussion 98
Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos and Gavin Thurston Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis 106
Discussion 121
Georg Breier, Alexander H. Licht, Anke Nicolaus, Anne Klotzsche, Ben Wielockx and Zuzana Kirsnerova HIF in vascular development and tumour angiogenesis 126
Discussion 133
Karina Yaniv, Sumio Isogai, Daniel Castranova, Louis Dye, Jiro Hitomi and Brant M. Weinstein Imaging the developing lymphatic system using the zebrafish 139
Discussion 148
Frances High and Jonathan A. Epstein Signalling pathways regulating cardiac neural crest migration and differentiation 152
Discussion 161
Ralf H. Adams Investigation of the angiogenic programme with tissue-specific and inducible genetic approaches in mice 165
Discussion 171
Gary K. Owens Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity 174
Discussion 191
Andrea Lundkvist, Sunyoung Lee, Luisa Iruela-Arispe, Christer Betsholtz and Holger Gerhardt Growth factor gradients in vascular patterning 194
Discussion 201
Deborah A. Freedman, Yasushige Kashima and Kenneth S. Zaret
Endothelial cell promotion of early liver and pancreas development 207
Discussion 216
Jörg Wilting, Kerstin Buttler, Jochen Rössler, Susanne Norgall, Lothar Schweigerer, Herbert A. Weich and Maria Papoutsi
Embryonic development and malformation of lymphatic vessels 220
Discussion 227
Joaquim Miguel Vieira, Quenten Schwarz and Christiana Ruhrberg
Role of the neuropilin ligands VEGF164 and SEMA3A in neuronal and vascular patterning in the mouse 230
Discussion 235
Final discussion 238
Tracheal tube development in Drosophila 238
Closing remarks 240
Contributor index 242
Subject index 244
