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Novartis Foundation Symposium 280 - Sepsis: NewInsights, New Therapies
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  • Wiley

More About This Title Novartis Foundation Symposium 280 - Sepsis: NewInsights, New Therapies

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Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response.
  • Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it
  • Describes numerous pharmacological approaches to therapy for early and late sepsis
  • Includes detailed discussion of the various physiological systems implicated in sepsis
  • Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis

Sepsis: New Insights, New Therapies is an invaluable resource for all critical care physicians and researchers. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists.

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The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Chairman: Mitchell Fink
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Symposim on Sepsis: new insights, new therapies, held at the Novartis Foundation, London, 14-16 February 2006.

Editors: Derek J. Cahdwick (Organizer) and Jamie Goode.

This Symposim was based on a proposal made by Mitchell Fink and Mervyn Singer.

Chair’s introduction (Mitchell P. Fink).

Discussion.

Strategies to modulate cellular energetic metabolism during sepsis (Alessandro Prottiand Mervyn Singer).

Discussion.

Immunostimulation is a rational therapeutic strategy in sepsis (Jérôme Pugin).

Discussion.

Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis (Alfred Ayala, Doreen E. Wesche-Soldato, Mario Perl, Joanne L. Lomas-Neira, Ryan Swanand Chun-Shiang Chung).

Discussion.

Modulating neutrophil apoptosis (John C. Marshall, Zeenat Malamand Songhui Jia).

Discussion.

HMGB1 as a potential therapeutic target(Haichao Wang, Wei Li, Richard Goldstein, Kevin J. Traceyand Andrew E. Sama).

Discussion.

Poly (ADP-ribose) polymerase activation and circulatory shock (Csaba Szabó).

Discussion.

Choosing the right substrate (Xavier Leverve, Cécile Batandierand Eric Fontaine).

Discussion.

Inhibiting glycogen synthase kinase 3β in sepsis (Laura Dugo, Marika Collin, David A. Allen, Nimesh S.A. Patel, Inge Bauer, Eero M. A. Mervaala, Marjut Louhelainen, Simon J. Foster, Muhammad M. Yaqooband Christoph Thiemermann).

Discussion.

Ethyl pyruvate: a novel treatment for sepsis (Mitchell P. Fink).

Discussion.

General discussion I.

Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models(Stefan W. Ryter and Augustine M. K. Choi).

Discussion.

The hypothalamic pituitary adrenal axis in sepsis (Andrea Polito, Jérôme AboabandDjillali Annane).

Discussion.

Modulating the endocrine response in sepsis: insulin and blood glucose control (Ilse Vanhorebeek, Lies Langoucheand Greet Van den Berghe).

Discussion.

The neuronal strategy for inflammation(Luis Ulloaand Ping Wang).

Discussion.

Beta-blockade in burns (C. T. Pereira, M. G. Jeschkeand D. N. Herndon).

Discussion.

System interactions (Mervyn Singer).

Discussion.

Protecting the permeability pore and mitochondrial biogenesis (C. A. Piantadosi, M. S. Carraway, D. W. Hadenand H. B. Suliman).

Discussion.

Contributor Index.

Subject index.

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