Title Details

Syed A. Abutalib, MD, is Assistant Director for Stem Cell Transplantation at the Chicago-area branch of Cancer Treatment Centers of America, or CTCA. CTCA is a group of five private treatment centers in the USA focused on patient care in oncology. For several years now, Dr. Abutalib has authored the very popular and well-received "Clinical Conundrums" feature in the oncologist tabloid paper Clinical Oncology (McMahon Publishing), and this is where the idea came to him to enhance and expand his concept from that experience into this book.

Maurie Markman, MD, is Senior Vice President of Clinical Affairs and National Director of Medical Oncology at Cancer Treatment Centers of America (CTCA). A nationally-renowned oncologist, Dr. Markman has more than 20 years of experience in cancer treatment and gynecologic research at some of the country’s most recognized facilities. Dr. Markman has served as the Vice President for Clinical Research and Chairman of the Department of Gynecologic Medical Oncology at M.D. Anderson Cancer Center in Houston, Texas. Prior to that, Dr. Markman spent 11 years as Chairman of the Department of Hematology/Oncology and Director of the Taussig Cancer Center at the Cleveland Clinic Foundation. He also spent five years as Vice Chairman of the Department of Medicine at Memorial Sloan-Kettering Cancer Center in New York.

List of Contributors, x

Preface, xxi

Section 1 Malignant Hematology and Hematopoietic Cell Transplantation

Part 1 Acute Lymphoblastic Leukemia in Adults

1 Diagnosis of acute lymphoblastic leukemia, 5
Frederick G. Behm, Agatha Bogard, Syed A. Abutalib, and Sujata S. Gaitonde

2 Prognostic markers and models in acute lymphoblastic leukemia, 18
Dieter Hoelzer

3 Management of B-cell acute lymphoblastic leukemia, 22
Hady Ghanem, Hagop Kantarjian, Nitin Jain, and Elias Jabbour

4 Management of T-cell acute lymphoblastic leukemia, 29
Daniel J. DeAngelo

5 Minimal residual disease in acute lymphoblastic leukemia, 35
Meir Wetzler

6 Hematopoietic cell transplantation in adult acute lymphoblastic leukemia, 40
Netanel A. Horowitz and Jacob M. Rowe

Part 2 Acute Myeloid Leukemia in Adults

7 Prognosis in acute myeloid leukemia: cytogenetics and beyond, 51
Gordana Raca, Madina Sukhanova, and Lucy A. Godley

8 Induction therapy in acute myeloid leukemia, 58
Tapan Kadia and Farhad Ravandi

9 Consolidation therapy in acute myeloid leukemia, 67
Gregory K. Behbehani and Bruno C. Medeiros

10 Management of acute promyelocytic leukemia, 71
Eytan M. Stein and Martin S. Tallman

11 Minimal residual disease in acute myeloid leukemia, 76
Hans Beier Ommen, Line Nederby, Marie Toft-Petersen, Charlotte Guldborg Nyvold, and Peter Hokland

12 Relapsed and refractory acute myeloid leukemia, 82
Stefan H. Faderl

13 Hematopoietic cell transplantation in acute myeloid leukemia, 89
Antonio M. Jimenez and Stefan O. Ciurea

Part 3 Myelodysplastic Syndromes and Related Disorders

14 Pitfalls in the diagnosis of myelodysplastic syndromes, 99
Jay Yang, Gail Bentley, and Charles A. Schiffer

15 Cytogenetics and prognostic models in myelodysplastic syndromes, 106
Uma Borate and Harry P. Erba

16 Management of myelodysplastic syndromes, 113
Vu H. Duong, Alan F. List, and Rami S. Komrokji

17 Management of therapy-related myeloid neoplasms, 120
Jagoda K. Jasielec and Richard A. Larson

18 Hematopoietic cell transplantation in myelodysplastic syndromes, 126
Antonio Di Stasi, Armin Ghobadi, and Partow Kebriaei

19 Acquired aplastic anemia, 131
Valeria Visconte and Ramon V. Tiu

Part 4 Myeloproliferative Neoplasms

20 Diagnostic approach in myeloproliferative neoplasms, 137
Ayalew Tefferi

21 Chronic myeloid leukemia: chronic phase, 142
Jerald P. Radich

22 Blast crisis of chronic myeloid leukemia, 147
Michael J. Mauro

23 Chronic myeloid leukemia and pregnancy, 150
Michael J. Mauro

24 Polycythemia vera, 152
Constantine S. Tam and Srdan Verstovsek

25 Essential thrombocytosis, 156
Paola Guglielmelli and Alessandro M. Vannucchi

26 Primary myelofibrosis, 162
Ayalew Tefferi

27 Eosinophilic myeloproliferative disorders, 167
Jason Gotlib

28 Chronic myelomonocytic leukemia, 176
Mrinal M. Patnaik

29 Hematopoietic cell transplantation in chronic myeloid leukemia, 180
Jerald P. Radich

30 Hematopoietic cell transplantation in primary myelofibrosis, 187
Irum Khan and Damiano Rondelli

Part 5 Chronic Lymphocytic and Other Leukemias

31 Prognostic markers and management of chronic lymphocytic leukemia, 195
Courtney D. DiNardo and Susan O’Brien

32 Hematopoietic cell transplantation in chronic lymphocytic leukemia, 201
Michael R. Bishop

33 Prolymphocytic leukemia, 207
Claire Dearden

34 Hairy cell leukemia, 220
Justin M. Watts and Martin S. Tallman

Part 6 Hodgkin Lymphoma

35 Management of classical Hodgkin lymphoma, 229
Kristen Sanfi lippo and Nancy L. Bartlett

36 Nodular lymphocyte-predominant Hodgkin lymphoma, 235
Dennis A. Eichenauer

37 Hematopoietic cell transplantation in Hodgkin lymphoma, 240
Tsiporah Shore and Koen van Besien

Part 7 Non-Hodgkin’s Lymphomas

38 Pitfalls in the diagnosis of non-Hodgkin’s lymphomas, 247
Carmen Barcena and Laurence de Leval

39 Follicular lymphoma, 257
Myron S. Czuczman

40 Diffuse large B-cell lymphoma, 263
Andrew D. Zelenetz

41 Mantle cell lymphoma, 270
Stephen Smith and John Sweetenham

42 Marginal zone lymphoma, 275
Sarah Rutherford, Wayne Tam, and Peter Martin

43 Primary mediastinal large B-cell lymphoma, 282
Pier Luigi Zinzani

44 Burkitt lymphoma, 286
Mark Roschewski and Wyndham Wilson

45 Gray zone lymphoma, 290
Caron A. Jacobson and Ann S. LaCasce

46 Transformed lymphoma, 295
Stephane Doucet and Jane N. Winter

47 HIV-associated lymphoma, 304
Kieron Dunleavy

48 Primary CNS lymphoma, 308
Nicholas A. Blondin, Joachim M. Baehring, and Fred H. Hochberg

49 Primary cutaneous lymphoma, 316
Thomas M. Habermann

50 Mycosis fungoides and Sézary syndrome, 323
Stephane Dalle, Marie Perier-Muzet, Brigitte Balme, and Luc Thomas

51 Hematopoietic cell transplantation in indolent non-Hodgkin’s lymphoma, 327
Saurabh Chhabra and Ginna G. Laport

52 Hematopoietic cell transplantation in diffuse large B-cell lymphoma, 332
Syed A. Abutalib and Istvan Redei

53 Hematopoietic cell transplantation in T-cell non-Hodgkin’s lymphomas, 339
Lori S. Muffly and Sonali M. Smith

Part 8 Plasma Cell Neoplasms and Related Disorders

54 Smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, 347
Robert A. Kyle

55 Risk stratification and response assessment in multiple myeloma and Waldenström’s macroglobulinemia, 352
Silvia Gentili and Sagar Lonial

56 Treatment of multiple myeloma, 358
Cindy Varga, Claudia Paba Prada, Kenneth Anderson, and Paul Richardson

57 Light-chain amyloidosis, 366
David C. Seldin

58 Waldenström’s macroglobulinemia, 371
Anita D’Souza and Morie A. Gertz

59 Autologous hematopoietic cell transplantation in multiple myeloma, 376
Jean-Luc Harousseau and Mohamad Mohty

60 Allogeneic hematopoietic cell transplantation in multiple myeloma, 381
Jasleen Randhawa, Veerpal Singh, and Parameswaran Hari

Part 9 Special Issues in Hematology

61 Role of PET scan in lymphomas, 391
Matthew A. Lunning and James O. Armitage

62 Radioimmunotherapy in lymphomas, 398
Reem Karmali and Stephanie A. Gregory

63 Radiation oncology consultation for hematologic malignancies, 403
Chris R. Kelsey and Leonard R. Prosnitz

Part 10 Special Issues in Hematopoietic Cell Transplantation

64 Donor and graft selection in allogeneic hematopoietic cell transplantation, 411
Jose Leonel Ochoa-Bayona and Claudio Anasetti

65 Preparative regimens in allogeneic hematopoietic cell transplantation for malignant hematological
diseases, 417
Robert J. Soiffer

66 T-cell depletion in allogeneic hematopoietic cell transplantation, 421
Jenna D. Goldberg and Miguel-Angel Perales

67 Prevention and treatment of relapse following hematopoietic cell transplantation, 426
Robert Chen, Sandra Thomas, and Stephen J. Forman

68 Acute graft-versus-host disease, 432
Andrew C. Harris and John E. Levine

69 Chronic graft-versus-host disease, 438
Carrie L. Kitko and Daniel R. Couriel

Section 2 Oncology

Part 1 Central Nervous System Tumors

70 Primary brain tumors, 449
Barbara J. O’Brien and Mark R. Gilbert

71 Secondary brain and spinal cord tumors, 457
Rimas V. Lukas, Patrik Gabikian, and Steven J. Chmura

Part 2 Head and Neck Cancers and Thoracic Malignancies

72 Medical management of head and neck cancers, 467
Tobenna Nwizu and David Adelstein

73 Endocrine malignancies, 476
Ann W. Gramza

74 Methodological and practical challenges for personalized therapies in non-small-cell lung cancer, 480
Ignacio I. Wistuba

75 Screening, staging, and stage I non-small-cell lung cancer, 486
Tarek M. Mekhail

76 Stage II and III non-small-cell lung cancer, 493
Grzegorz Korpanty and Natasha B. Leighl

77 Recurrent and metastatic non-small-cell lung cancer and novel targets, 500
Evan Pisick and Ravi Salgia

78 Small-cell lung cancer, 503
Stephen V. Liu and Glen J. Weiss

79 Mesothelioma, 506
Christopher W. Towe and Harvey I. Pass

Part 3 Breast Cancer

80 Immunohistochemistry testing and beyond in breast cancer, 515
Alejandro A. Gru and D. Craig Allred

81 Prevention and adjuvant therapy in breast cancer, 523
Faithlore P. Gardner and Edith A. Perez

82 Preoperative systemic therapy for breast cancer, 532
Virginia Kaklamani and William J. Gradishar

83 Recurrent and metastatic breast cancer, 540
Dennis L. Citrin

84 Special issues in the young and pregnant patient with breast cancer, 546
Hatem A. Azim Jr. and Fedro A. Peccatori

Part 4 Gastrointestinal Oncology

85 Early-stage esophageal and stomach cancers, 555
M. Naomi Horiba and Yixing Jiang

86 Metastatic esophagogastric cancer: controversies, consensus, and new targets, 562
Geoffrey Y. Ku and David H. Ilson

87 Early-stage colorectal cancer, 567
Vaibhav Sahai and Al B. Benson III

88 Recurrent and metastatic colorectal cancer: controversies, consensus, and new targets, 573
Davendra Sohal and Robert J. Pelley

89 Pancreatic cancer, 581
Katherine Van Loon and Margaret Tempero

90 Hepatobiliary cancer, 590
Keith Stuart

91 Neuroendocrine tumors, 595
Anya Litvak and Leonard Saltz

92 Transarterial liver-directed therapies in oncology, 601
Divyesh G. Mehta and Jeffery Choh

93 Anal cancer, 606
Rob Glynne Jones

Part 5 Genitourinary Oncology

94 Renal cancer: tumor diversity, molecular taxonomy, and prognostic algorithms, 615
Henry J. Conter and Eric Jonasch

95 Medical management of renal cancer, 621
Gary R. MacVicar and Timothy M. Kuzel

96 Medical management of bladder cancer, 628
Gary R. MacVicar and Timothy M. Kuzel

97 Prostate cancer: Screening, surveillance, prognostic algorithms and independent pathologic predictive
parameters, 634
Megan G. Lockyer and Thomas M. Wheeler

98 Medical management of prostate cancer, 638
Elizabeth K. O’Donnell and Philip Kantoff

99 Germ cell tumors, 645
Timothy Gilligan

Part 6 Skin Malignancies

100 Medical management of melanoma, 653
Ana M. Ciurea and Kim Margolin

101 Nonmelanoma skin cancers, 661
Daniel Christiansen and Anna Sancho Clayton

PART 7 Gynecological Malignancies

102 Ovarian cancer: neoadjuvant, adjuvant, and surgical issues, 669
Alpa M. Nick and Robert L. Coleman

103 Ovarian cancer: second-line treatment strategies, 675
Maurie Markman

104 Endometrial and cervical cancers, 681
Maurie Markman

PART 8 Sarcomas

105 Bone sarcomas, 689
Nicole Larrier, William C. Eward, and Richard F. Riedel

106 Soft tissue sarcomas, 696
Neeta Somaiah and Shreyaskumar Patel

PART 9 Multidisciplinary Approach: Consultation with Surgical Oncology Team

107 Surgical aspects of head and neck cancers, 707
Constance E.H. Teo and Randal S. Weber

108 Surgical aspects of thoracic malignancies, 711
Albert S.Y. Chang, Thomas A. D’Amico, and David C. White

109 Surgical aspects of upper gastrointestinal cancers, 719
Sabha Ganai and Mitchell C. Posner

110 Surgical aspects of pancreatic cancer, 723
Amanda B. Cooper, Ching-Wei D. Tzeng, and Matthew H.G. Katz

111 Surgical aspects of hepatobiliary tumors, 729
Subhasis Misra and Leonidas Koniaris

112 Surgical aspects of lower gastrointestinal cancers, 735
Anthony J. Senagore

113 Surgical aspects of renal cancer, 739
Michael E. Woods and Matthew C. Raynor

114 Surgical aspects of bladder cancer, 744
Michael B. Williams

115 Surgical aspects of prostate cancer, 747
Peter Pinto

116 Surgical aspects of melanoma, 754
Thomas Velancia

PART 10 Multidisciplinary Approach: Consultation with Radiation Oncology Team

117 Radiotherapy for head and neck cancers, 761
Shiyu Song

118 Radiotherapy for ductal carcinoma in situ (DCIS), 767
Beryl McCormick

119 Radiotherapy for early-stage invasive breast cancer, 771
Julia White

120 Radiotherapy for thoracic malignancies, 778
Meredith E. Giuliani and Andrea Bezjak

121 Radiotherapy for gastrointestinal malignancies, 785
Manisha Palta, Christopher Willett, and Brian Czito

122 Radiotherapy for genitourinary malignancies, 789
Christina H. Chapman and Curtiland Deville

PART 11 Hereditary Cancer Syndromes and Genetic Testing in Oncology

123 When to suspect hereditary cancer syndromes, 795
Emily Dalton and Kathy Schneider

124 Hereditary breast cancer syndromes, 800
Kathy Schneider and Emily Dalton

125 Genetic testing in gastrointestinal tumors, 804
Kristen M. Shannon and Daniel C. Chung

126 Hereditary urogenital cancer syndromes, 810
Melanie Corbman and Eric Fowler

PART 12 Special Issues in Hematology and Oncology

127 Carcinoma of unknown primary (CUP), 817
Isabella C. Glitza and Gauri R. Varadhachary

128 Geriatric oncology, 822
Nayana Kamath and Supriya Gupta Mohile

129 Nuts and bolts of cancer immunotherapy, 826
Christopher R. Heery and James L. Gulley

130 Controversies related to oncology clinical trial development, 831
Elihu H. Estey

131 PET scan in oncology, 835
Shaunagh McDermott and Michael A. Blake

132 Hematopoietic growth factors, 841
LeAnn B. Norris, Jametta Magwood, and Charles L. Bennett

133 Anticoagulation issues in oncology, 844
Steven M. Corsello and Jean Marie Connors

134 Symptom management and palliative care, 851
Rony Dev and Eduardo D. Bruera

135 Metabolic and nutritional issues in oncology, 860
Julia Fechtner, Carolyn Lammersfeld, Carol Ireton-Jones, and Pankaj Vashi

136 Bone-related issues in oncology, 867
S. Mujtaba Rizvi, Helen Collins, and Alan Lipton

137 Integrative medicine in oncology, 872
Weidong Lu and David S. Rosenthal

138 Naturopathic medicine in oncology, 879
Christina M. Shannon, Tracey Thomas, and Shauna Birdsall

139 Anesthesiology consultation for localized cancer pain, 884
Abed Rahman, Magdalena Anitescu, and Raed Rahman

140 Musculoskeletal care in oncology, 893
James E. Rosenberg and Charles A. McDonald

141 Cancer survivorship and psychosocial issues in oncology, 896
Jabeen Abutalib, Shahid Raza, and Laura Sunn

Index, 902

Color plate section facing p.522