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More About This Title Epilepsy
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Epilepsy is a complicated neurological condition with variable manifestations, numerous etiologies, and a diverse range of treatments. It is a chronic disease that, in many cases, can be controlled. However, treatment requires accurate clinical evaluation to allow intelligent treatment choices. Epilepsy has been designed to help clinicians develop these evaluation skills. Expert neurologists have distilled the evidence and combined their experience.
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John W. Miller, MD, PhD, University of Washington, Seattle, WA, USA
Howard P. Goodkin, MD, PhD, University of Virginia, Charlottesville, VA, USA
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Contributor List ix
Series Foreword xiii
Preface xv
Part I: Epilepsy Basics
1 Recognizing Seizures and Epilepsy: Insights from Pathophysiology 3
Carl E. Stafstrom
2 Classifying Epileptic Seizures and the Epilepsies 10
Valeria M. Muro and Mary B. Connolly
3 What Causes Epilepsy? 15
Anna Rosati and Renzo Guerrini
4 Epidemiology of Seizures and Epilepsy 28
Aidan Neligan and Josemir W. Sander
Part II: Working up Seizures and Epilepsy
5 Diagnosing and Localizing Seizures at the Bedside and in Clinic 35
Joseph I. Sirven
6 Psychogenic Nonepileptic Episodes 42
Vaishali S. Phatak
7 What Can the EEG Tell Us? 45
Mark Quigg
8 What Can Neuroimaging Tell Us? 54
Edward J. Novotny
9 Workup of New-Onset Seizures 61
Jennifer Langer
10 Evaluation of the Patient with Medically Refractory Epilepsy 67
Gregory L. Holmes
Part III: Using Antiepileptic Medications
11 Choosing, Initiating, Adjusting, and Changing Antiepileptic Medications 77
John W. Miller
12 Antiepileptic Drug Adverse Effects: What to Watch Out For 84
Jacquelyn L. Bainbridge and Caleb Y. Oh
13 Antiepileptic Drug Interactions 91
Philip N. Patsalos
14 Recognizing Intractability to Antiepileptic Medication 102
Bassel W. Abou-Khalil
15 Optimizing Antiepileptic Drug Therapy in Refractory Epilepsy 107
Nicholas P. Poolos
16 Rescue Medications for Home Treatment of Acute Seizures 112
Peter Wolf and Rûta Mameniškienë
17 When and How to Stop Antiepileptic Drugs 118
John D. Hixson
18 Using Parenteral Antiepileptic Medications 122
Jane G. Boggs
19 Pharmacopeia 126
Gail D. Anderson
Part IV: Special Topics in Pediatric Epilepsy
20 Seizures in the Neonate 141
Adam L. Hartman and Frances J. Northington
21 Benign and Malignant Childhood Epilepsies 147
Katherine C. Nickels and Elaine C. Wirrell
22 Epilepsy: When to Perform a Genetic Analysis 159
Heather E. Olson and Annapurna Poduri
23 Metabolic Disorders Not to Miss 167
Phillip L. Pearl and Yuezhou Joe Yu
Part V: Special Topics in Adult Epilepsy
24 Juvenile Myoclonic Epilepsy and Other Primary Generalized Epilepsies 177
Shahin Hakimian
25 Epilepsy in Women of Childbearing Age 184
Autumn Klein
26 Epilepsy After Sixty 189
Edward Faught
Part VI: What can be done when medication doesn’t work?
27 When Should Epilepsy Neurosurgery Be Considered, and What Can It Accomplish? 199
Paul A. Garcia
28 When Should Vagus Nerve Stimulation Be Considered, and What Can It Accomplish? 205
Pearce J. Korb and Sandra L. Helmers
29 Ketogenic Diet and Alternative Therapies 210
Dana Ekstein and Steven C. Schachter
Part VII: How are acute seizures and status epilepticus evaluated and treated in the emergency department and the hospital?
30 acute Symptomatic Seizures in Children and Adults: Evaluation and Treatment 217
J. Stephen Huff and Jessica L. Carpenter
31 Evaluating and Treating Status Epilepticus 222
Jeffrey Bolton and Howard P. Goodkin
32 Recognizing, Assessing, and Treating Seizures and Status Epilepticus in the ICU 227
Nicolas Gaspard and Lawrence J. Hirsch
Part VIII: The morbidity and mortality of epilepsy
33 mortality in Epilepsy 243
Elizabeth J. Donner
34 Accidents in Epilepsy 248
Allan Krumholz and Ana M. Sanchez
35 Medical Comorbidity in Epilepsy 253
Kimberly L. Pargeon and Sheryl R. Haut
36 Cognitive Effects of Chronic Epilepsy 260
Daniel L. Drane
37 Recognizing and Treating Psychiatric Comorbidity in Epilepsy 268
Jay Salpekar
Index 275
Color plate section between pages 80 and 81