Title Details

About the Editors
EUGENE R. SCHIFF MD, MACP, FRCP, MACG, FAASLD is Professor of Medicine, University of Miami Miller School of Medicine, and Director, Schiff Center for Liver Diseases, Miami, USA.

WILLIS C. MADDREY MD, MACP, FRCP, FAASLD is Professor of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.

K. RAJENDER REDDY MD, FAASLD is Ruimy Family President's Distinguished Professor of Medicine, Director of Hepatology, and Medical Director of Liver Transplantation, University of Pennsylvania, Philadelphia, USA.

Contributors, viii

Foreword, xiii

Preface, xiv

About the Companion Website, xvi

Part I Overview: Clinical Fundamentals of Hepatology

1 History Taking and Physical Examination for the Patient with Liver Disease, 3
Esperance A. Schaefer and Lawrence S. Friedman

2 Laboratory Tests, Noninvasive Markers of Fibrosis, Liver Biopsy, and Laparoscopy, 17
Michael P. Curry and Lennox J. Jeffers

3 Noninvasive and Invasive Imaging of the Liver and Biliary Tract, 38
Koushik K. Das, Matthew A.Morgan, and Gregory G. Ginsberg

Part II General Considerations

4 Physioanatomic Considerations, 73
Ian R. Wanless

5 Bilirubin Metabolism and Jaundice, 103
Allan W. Wolkoff and Paul D. Berk

6 Hepatic Histopathology, 135
Zachary D. Goodman

7 Mechanisms of Liver Injury, 200
Harmeet Malhi and Gregory J. Gores

8 Hepatic Manifestations of Systemic Disorders, 218
Stuart C. Gordon and Humberto C. Gonzalez

9 The Liver in Pregnancy, 244
Nancy Reau and Yannick Bacq

Part III Consequences of Liver Disease

10 Hepatic Fibrosis, 271
Scott L. Friedman

11 Preoperative Evaluation of the Patient with Liver Disease, 290
Patrick S. Kamath and Mark T. Keegan

12 Management of Portal Hypertension, 304
Guadalupe Garcia-Tsao and Juan G. Abraldes

13 Renal Complications of Liver Disease and the Hepatorenal Syndrome, 336
Xingxing S. Cheng and W. Ray Kim

14 Pulmonary Manifestations of Liver Disease, 353
Michael B. Fallon and Anil Seetharam

15 Ascites and Spontaneous Bacterial Peritonitis, 365
Vicente Arroyo and Javier Fern´andez

16 Hepatic Encephalopathy, 387
Chathur Acharya and Jasmohan S. Bajaj

17 Acute Liver Failure, 411
Robert J. Fontana and Khurram Bari

18 Acute-on-Chronic Liver Failure, 432
Florence Wong

19 Malnutrition and Liver Disease, 460
Craig McClain, Irina Kirpich, and Laura Smart

Part IV Cholestatic Disorders

20 Primary Sclerosing Cholangitis, 491
John M. Vierling

21 Primary Biliary Cholangitis, 523
Cynthia Levy, Andres F. Carrion, and Marlyn J. Mayo

22 Autoimmune Hepatitis, 546
Gideon M. Hirschfield and Gwilym J. Webb

Part V Viral Hepatitis

23 Hepatitis A and E, 565
Kenneth E. Sherman and Shyam Kottilil

24 Hepatitis B and D, 584
Marc G. Ghany and Naveen Gara

25 Hepatitis C, 628
Michael W. Fried, Jama M. Darling, and Stanley M. Lemon

Part VI Alcohol- and Drug-induced Liver Disease

26 Alcoholic Liver Disease, 701
Mack C. Mitchell and Gyongyi Szabo

27 Drug-induced Hepatotoxicity, 740
Dominique Larrey, Jose Ursic-Bedoya, and Lucy Meunier

28 Mechanisms of Drug-induced Liver Injury, 774
Paul B. Watkins and Merrie Mosedale

Part VII Genetic and Metabolic Disease

29 Wilson Disease, 801
Michael L. Schilsky and Aftab Ala

30 Hemochromatosis and Iron Storage Disorders, 820
Kris V. Kowdley and Priya Handa

31 Alpha-1 Antitrypsin Deficiency, 843
David H. Perlmutter

32 Nonalcoholic Fatty Liver Disease, 867
Curtis K. Argo, Zachary H. Henry, and Stephen H. Caldwell

Part VIII Vascular Diseases of the Liver

33 Vascular Liver Disease, 911
Dominique-Charles Valla

34 The Liver in Circulatory Failure, 935
Santiago J. Munoz, Hanisha R. Manickavasagan, and Idean Amirjazil

Part IX Benign and Malignant Tumors; Cystic Disorders

35 Benign Tumors, Nodules, and Cystic Diseases of the Liver, 949
Julien Calderaro and Jessica Zucman-Rossi

36 Hepatocellular Carcinoma, 977
Maddie Kubiliun and Jorge A. Marrero

37 Surgical Options in Liver Cancers, 989
Garrett R. Roll and John Paul Roberts

Part X Infectious and Granulomatous Disease

38 Amoebic and Pyogenic Liver Abscesses, 1005
Marco A. Olivera-Mart´ınez and David Kershenobich

39 Parasitic Diseases, 1013
Michael A. Dunn

40 Granulomas of the Liver, 1028
James H. Lewis

Part XI Elements of Liver Transplantation

41 Selection of Candidates and Timing of Liver Transplantation, 1055
Meaghan Phipps, Alyson N. Fox, and Robert S. Brown Jr.

42 Immunosuppression: The Global Picture, 1065
Caroline C. Jadlowiec, Timucin Taner, and Russell H. Wiesner

43 The First Six Months Following Liver Transplantation, 1079
K. Rajender Reddy and Manuel Mendizabal

44 Long-term Management of the Liver Transplant Patient, 1093
Timothy M. McCashland

45 The Liver Transplant Procedure, 1107
Bijan Eghtesad, Koji Hashimoto, and John Fung

46 Recurrent Disease Following Liver Transplantation, 1127
Haripriya Maddur and Josh Levitsky

47 The Role of Retransplantation, 1143
Peter L. Abt and Kim M. Olthoff

48 Controversies in Liver Transplantation, 1156
James F. Trotter

Index, 1169