Title Details

The editors
Jim E. Riviere, DVM, PhD, DSc (hon), ATS, is The MacDonald Chair in Veterinary Medicine, University Distinguished Professor, Kansas Bioscience Eminent Scholar, and Director, Institute of Computational Comparative Medicine at Kansas State University in Manhattan, Kansas, USA. He is also a Distinguished Professor Emeritus at North Carolina State University in Raleigh, North Carolina, USA.

Mark G. Papich, DVM, MS, Diplomate ACVCP, has the Burroughs Wellcome Professorship in Veterinary Pharmacology and is a Professor of Clinical Pharmacology, Department of Molecular Biomedical Sciences, College of Veterinary Medicine at North Carolina State University in Raleigh, North Carolina, USA.

Contributors    xiii

Preface    xix

About the Companion Website    xxi

Section ÆÌ Principles of Pharmacology   1

Veterinary Pharmacology: An Introduction to the Discipline   3
Jim E. Riviere and Mark G. Papich

Absorption, Distribution, Metabolism, and Elimination   8
Jim E. Riviere

Pharmacokinetics   41
Jim E. Riviere

Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine   65
Pierre-Louis Toutain

Principles of Pharmaceutics and Veterinary Dosage Forms   87
Raafat M. Fahmy and Marilyn N. Martinez

Section ?f Drugs Acting on the Autonomic Nervous System   111

Introduction to the Autonomic Nervous Systemand Autonomic Pharmacology   113
Joshua A. Rowe, RoseM.McMurphy, Barbara J. Lutjemeier, andMichael J. Kenney

 Adrenergic Receptor Agonists and Antagonists   131
Rose M.McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and Michael J. Kenney

Cholinergic Pharmacology: Autonomic Drugs   151
RoseM.McMurphy, Elizabeth G. Davis, Amy J. Rankin,Marjory A. Artzer, Barbara J. Lutjemeier, andMichael J. Kenney

Section ?g Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System   165

Introduction to Drugs Acting on the Central Nervous Systemand Principles of Anesthesiology 167
Peter J. Pascoe and Eugene P. Steffey

Neuromuscular Blocking Agents  194
Diane E.Mason and Christopher L. Norkus

Inhalation Anesthetics   216
Robert J. Brosnan and Eugene P. Steffey

Injectable Anesthetic Agents   247
Lysa P. Posner

Opioid Analgesic Drugs   281
Butch KuKanich andMark G. Papich

Sedatives and Tranquilizers   324
Lysa P. Posner

Local Anesthetics   369
Thomas W. Vickroy

Euthanizing Agents   387
Anna Hampton

Anticonvulsant Drugs   395
Mark G. Papich

Drugs Affecting Animal Behavior   416
Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich

Section ?h Autacoids and Antiinflammatory Drugs   449

Histamine, Serotonin, and their Antagonists   451
Wolfgang B¨aumer

Analgesic, Antiinflammatory, Antipyretic Drugs   467
Peter Lees

Section ?i Drugs Acting on the Cardiovascular System 501

Digitalis, Positive Inotropes, and Vasodilators   503
Clarke E. Atkins and Marisa K. Ames

Antiarrhythmic Agents   537
Kathryn M. Meurs and Jim E. Riviere

Section ?j Drugs Affecting Renal Function and Fluid–Electrolyte Balance   553

Principles of Acid–Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes    555
Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar

Diuretics and Renal Pharmacology   593
Butch Kukanich and Deborah T. Kochevar

Section ?k Drugs Acting on Blood and Blood Elements   623

Anticoagulant, Antiplatelet, and Hemostatic Drugs   625
Mark G. Papich

Section ?l Endocrine Pharmacology   647

Hypothalamic and Pituitary Hormones   649
Srujana Rayalam,Margarethe Hoenig, and Duncan C. Ferguson

Hormones Affecting Reproduction   674
Wolfgang B¨aumer, C. Scott Bailey, and John Gadsby

Thyroid Hormone and Antithyroid Drugs   691
Duncan C. Ferguson

Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs   729
Duncan C. Ferguson and Margarethe Hoenig

 Drugs Influencing Glucose Metabolism   763
Margarethe Hoenig

Chemotherapy of Microbial Diseases   779

Antiseptics and Disinfectants   781
Megan E. Jacob

Sulfonamides and Potentiated Sulfonamides   796
Mark G. Papich

𝛃-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs   826
Mark G. Papich

Tetracycline Antibiotics   858
Mark G. Papich and Jim E. Riviere

Aminoglycoside Antibiotics   877
Mark G. Papich and Jim E. Riviere

Chloramphenicol and Derivatives, Macrolides, Lincosamides, andMiscellaneous Antimicrobials   903
Mark G. Papich

Fluoroquinolone Antimicrobial Drugs   953
Mark G. Papich

Antifungal and Antiviral Drugs   988
Jennifer L. Davis and LaraMaxwell

Section ÆÌ?e Chemotherapy of Parasitic Diseases  1033

Antinematodal Drugs   1035
Carlos E. Lanusse, JuanM. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez

Anticestodal and Antitrematodal Drugs   1081
Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel

Macrocyclic Lactones: Endectocide Compounds   1102
Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz

Antiprotozoan Drugs   1128
Jennifer L. Davis and Jody L. Gookin

Ectoparasiticides   1166
Ronald E. Baynes

Section ÆÌÆÌ Specialty Areas of Pharmacology   1189

Chemotherapy of Neoplastic Diseases   1191
Luke A.Wittenburg and Daniel L. Gustafson

Immunosuppressive Drugs   1226
Mark G. Papich

Drugs for Treating Gastrointestinal Diseases   1245
Mark G. Papich

Dermatopharmacology: Drugs Acting Locally on the Skin   1278
Jim E. Riviere and Rosanna Marsella

Drugs that Affect the Respiratory System   1302
Mark G. Papich

Ophthalmic Pharmacology   1321
Alison Clode

Pharmacogenomics   1332
Katrina L.Mealey

Considerations for TreatingMinor Food-Producing Animals with Veterinary Pharmaceuticals   1345
Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring

Unique Considerations Pertaining to the Use of Drugs in Food Animals   1358
Michael D. Apley

Pharmacology in Aquatic Animals   1373
Ron A.Miller

Zoological Pharmacology   1395
Robert P. Hunter

Section ÆÌ?f Regulatory and Other Considerations   1405

The Regulation of Animal Drugs   1407
Steven D. Vaughn andMarilyn N. Martinez

Veterinary Pharmacy  1427
Gigi Davidson andMark G. Papich

Medication Control Programs in Performance Animals   1439
Cynthia A. Cole

Pharmacovigilance   1448
John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer

Dosage Forms And Veterinary Feed Directives   1459
Geof Smith and Jim E. Riviere

Evidence-Based Pharmacotherapy   1465
Ronette Gehring

Chemical Residues In Tissues Of Food Animals   1469
Jim E. Riviere

Index   1481