Rights Contact Login For More Details
- Wiley
More About This Title Handbook of Metathesis - Catalyst Development andMechanism 2e V 2
English
The second edition of the "go-to" reference in this field is completely updated and features more than 80% new content, with emphasis on new developments in the field, especially in industrial applications. No other book
covers the topic in such a comprehensive manner and in such high quality.
Edited by the Nobel laureate R. H. Grubbs and D. J. O´Leary, Volume 2 of the 3-volume work focusses on applications in organic synthesis. With a list of contributors that reads like a "Who's-Who" of metathesis, this is an
indispensable one-stop reference for chemists in academia and industry.
View the set here - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527334246.html
Other available volumes:
Volume 1: Catalyst Development and Mechanism, Editors: R. H. Grubbs and A. G. Wenzel - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339485.html
Volume 3: Polymer Synthesis, Editors: R. H. Grubbs and E. Khosravi - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339507.html
English
Robert H. Grubbs received his Ph.D. from Columbia University for work with Ron Breslow. After a postdoctoral year with Jim Collman at Stanford University, he joined the faculty at Michigan State University. In 1978, he moved to the California Institute of Technology, where he is now the Victor and Elizabeth Atkins Professor of Chemistry. Among many other awards he received the Nobel Prize in 2005 for his research on the metathesis reaction. His research interests include polymer chemistry, organometallic catalysis, and development of new synthetic organic methodology.
Daniel J. O´Leary received his PhD at UCLA in the group of Prof. Frank A. L. Anet. Following an NSF postdoctoral fellowship with Prof. Yoshito Kishi at Harvard University, he became Assistant Professor at Pomona College, where he is presently the Carnegie Professor of Chemistry.His research interests are in the area of organic synthesis, isotope effects, and nuclear magnetic resonance.
English
About the Editors xxxiii
Preface xxxvii
List of Contributors of Volumes 1 and 2 xxxix
Abbreviations and Acronyms xli
Theory and instrumentation of mass spectrometry and its application to drug metabolism 393
Stacy L. Gelhaus and Ian A. Blair
Mass spectral interpretation 419
Li-Kang Zhang and Birendra N. Pramanik
Computational approaches in drug biotransformation studies: metabolite prediction 457
Nigel J. Waters and Michelle K. Dennehy
High-throughput metabolite detection and quantitative–qualitative bioanalysis 481
Donghui Cui and Sean Yu
Metabolic stability screen in drug discovery 499
Chuang Lu
Application of triple-quadrupole and its hybrid mass spectrometers for the identification of drug metabolites 523
Zhi-Yi Zhang, Chandra Prakash, and Lin Xu
Role of ion trap LC-MS techniques for the identification of drug metabolites 553
Robert D. Pelletier and W. George Lai
Drug metabolite identification with high-resolution mass spectrometry 567
Haiying Zhang and Mingshe Zhu
Strategies for the identification of unusual and novel metabolites using derivatization, hydrogen–deuterium exchange (HDX), and liquid chromatography-nuclear magnetic resonance (LC-NMR) spectroscopy techniques 591
Amin Kamel, Shawn Harriman, and Chandra Prakash
The use of nanoelectrospray mass spectrometry for the quantitation of metabolites in the absence of synthetic standards 619
Jing-Tao Wu
Quantitation of drug metabolites by radioactivity detection including accelerator mass spectrometry (AMS) 633
Angus N.R. Nedderman and Mark E. Savage
Application of quantitative NMR in drug metabolism studies 661
Abdul E. Mutlib
Early assessment of exposure of drug metabolites in humans using mass spectrometry 693
Natalia A. Penner, Joanna Zgoda-Pols, and Chandra Prakash
Profiling and characterization of bioactive substances of herbal medicine and their metabolites using mass spectrometry 723
Xiaoyan Chen
Application of in silico metabolism and environmental degradation data to support chemical PBT assessment 787
Sabcho Dimitrov, Gilman Veith, and Ovanes Mekenyan
