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More About This Title Workbook for Organic Synthesis - The DisconnectionApproach 2e
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Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition
This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student’s experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis.
Organic Synthesis: The Disconnection Approach, 2nd Edition
There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.
Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.
English
Dr Stuart Warren Department of Chemistry, University of Cambridge, UK
Dr Warren is the author of the bestselling textbooks "Organic Synthesis: The Disconnection Approach" (Wiley), "Organic Synthesis: Strategy and Control" (Wiley) and "Organic Chemistry" (OUP)
Dr Paul Wyatt
School of Chemistry, University of Bristol, UK.
Dr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning.?He is co-author, with Warren, of "Organic Synthesis: Strategy and Control"
English
Preface vii
General References ix
1. The Disconnection Approach 1
2. Basic Principles: Synthons and Reagents: Synthesis of Aromatic Compounds 5
3. Strategy I: The Order of Events 11
4. One-Group C–X Disconnections 15
5. Strategy II: Chemoselectivity 21
6. Two-Group C–X Disconnections 29
7. Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy 35
8. Amine Synthesis 41
9. Strategy IV: Protecting Groups 49
10. One-Group C–C Disconnections I: Alcohols 55
11. General Strategy A: Choosing a Disconnection 61
12. Strategy V: Stereoselectivity A 67
13. One-Group C–C Disconnections II: Carbonyl Compounds 75
14. Strategy VI: Regioselectivity 81
15. Alkene Synthesis 87
16. Strategy VII: Use of Acetylenes (Alkynes) 93
17. Two-Group C–C Disconnections I: Diels-Alder Reactions 99
18. Strategy VIII: Introduction to Carbonyl Condensations 105
19. Two-Group C–C Disconnections II: 1,3-Difunctionalised Compounds 111
20. Strategy IX: Control in Carbonyl Condensations 115
21. Two-Group C–C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation 123
22. Strategy X: Aliphatic Nitro Compounds in Synthesis 129
23. Two-Group Disconnections IV: 1,2-Difunctionalised Compounds 133
24. Strategy XI: Radical Reactions in Synthesis 139
25. Two-Group Disconnections V: 1,4-Difunctionalised Compounds 147
26. Strategy XII: Reconnection 153
27. Two-Group C–C Disconnections VI: 1,6-diCarbonyl Compounds 159
28. General Strategy B: Strategy of Carbonyl Disconnections 165
29. Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles 173
30. Three-Membered Rings 181
31. Strategy XIV: Rearrangements in Synthesis 189
32. Four-Membered Rings: Photochemistry in Synthesis 195
33. Strategy XV: The Use of Ketenes in Synthesis 201
34. Five-Membered Rings 207
35. Strategy XVI: Pericyclic Reactions in Synthesis: Special Methods for Five-Membered Rings 213
36. Six-Membered Rings 221
37. General Strategy C: Strategy of Ring Synthesis 227
38. Strategy XVII: Stereoselectivity B 235
39. Aromatic Heterocycles 245
40. General Strategy D: Advanced Strategy 255
Index 263
