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- Wiley
More About This Title Metabolism at a Glance 3e
English
Metabolism is a complicated subject involving complex molecules and interrelated pathways. These metabolic pathways are usually taught separately with the result that the student develops a detailed but compartmentalised approach to metabolism and frequently fails to see the overall picture and its physiological significance.
Using the at a Glance format, the book takes the student through a complete course in intermediary metabolism in an integrated manner. The same chart is repeated throughout the book with the individual pathway under study highlighted.
The book is an ideal text for introductory biochemistry courses and has established itself as an enormously popular book amongst lecturers and students alike. This third edition is fully updated and includes five new chapters to mirror those topics currently taught at undergraduate level:
1. Metabolic Channelling
2. Glucose homeostasis and Reye's Disease
3. Pentose phosphate pathway and the prodcution of NADPH
4. Tryptophan metabolism in health and disease
5. Tyrosine metabolism in health and disease
English
Foreword 8
Preface 9
1 Introduction to metabolic pathways 10
2 Biosynthesis of ATP I: ATP, the molecule that powers metabolism 12
3 Biosynthesis of ATP II: mitochondrial respiratory cheln 14
4 The oxidation of cytosolic NADH: the malate/aspartate shuttle and the glycerol phosphate shuttle 16
5 Metabolism of glucose to provide energy 18
6 Metabolism of one molecule of glucose yields 31 (or should it be 38?) molecules of ATP 20
7 Metabolism of glucose to glycogen 22
8 Anaerobic metabolism of glucose and glycogen to yield energy as ATP 24
9 2,3-Blsphosphoglycerate (2,3-BPG) and the red blood cell 26
10 Metabolism of glucose to fat (trlacylglycerol) 28
11 Metabolism of glucose to fatty acids and trlacylglycerol 30
12 The pentose phosphate pathway: the production of NADPH and reduced glutathione 32
13 Tha pyruvate/malate cycle and the production of NADPH 34
14 Mammals cannot synthesize glucose from fatty acids 36
15 Metabolism of trlacylglycerol to provide energy as ATP 38
16 Glycogen metabolism I 40
17 Glycogen metabolism II 42
18 Glycogen metabolism III: regulation of glycogen breakdown 44
19 Glycogen metabolism IV: regulation of glycogen synthesis 46
20 Regulation of glycolysis: overview exemplified by glycolysis In cardiac muscle 48
21 Glycolysis and the pentose phosphate pathway collaborate In liver to make fat 50
22 Glycolysis In skeletal muscle: biochemistry of sport and exercise 52
23 Regulation of gluconeogenesis 54
24 Regulation of Krebs cycle 56
25 Regulation of fatty acid oxidation: mobilization of fatty acids from storage In adipose tissue 56
26 Fatty acid oxidation and the carnitine shuttle 60
27 The ketone bodies 62
28 Ketone body utilization 64
28 II-Oxidation of unsaturated fatty acids 66
30 Peroxisomal II-oxidation 66
31 Elongation and desaturation of fatty acids 70
32 Cholesterol, bile acids and the steroid hormones 72
33 The omlthlne cycle for the production of urea: 'the urea cycle' 74
34 Metabolic chennelllng: enzymes are organized to enable chennelling of metabolic Intermediate. 76
35 Biosynthesis of the non-essential amino acids 78
36 Catabolism of amino acids I 80
37 Catabolism of amino acids II 82
38 Metabolism of amino acids to glucose in starvatlon and during the period Immediately after refeeding 84
39 Metabolism of protein to fat 86
40 Disorders of amino acid metabolism 88
41 Phenylalanine and tyresine metabolism 90
42 Tryptophan metabolism: the biosynthesis of NAD+, serotonin and melatonin 92
43 Amino acid metabolism, folate metabolism and the 'i-carbon pool' I: purine biosynthesis 94
44 Amino acid metabolism, folate metabolism and the 'i-carbon pool' II: pyrimidine biosynthesis 96
45 Porphyrin metabolism, haem and the bile pigments 98
46 Metabolism of ethanol 100
47 Sorbitol, galactitol, glucuronate and xylltol 102
48 Fructose metabolism 104
49 Metabolic pathways in fasting liver and their disorder in Reye's syndrome 106
50 Diabetes I: insulin-stimulated glucose uptake into cells and glycogen synthesis - signal transduction 1 08
51 Diabetes II: metabolic changes in Type 1 diabetes 110
52 Diabetes III: Type 1 diabetes, Type 2 diabetes, MODY and pancreatic poeell metabolism 112
53 Diabetes IV: Type 2 diabetes and insulin resistance in muscle 114
54 Diabetes V: Type 2 diabetes and insulin resistance in adipose tissue 116
55 Diabetes VI: Type 2 diabetes and insulin resistance in liver 118
Index 121
English
"...a highly comprehensive set of notes and pathway maps concentrated exclusively on metabolism. If you are after an easy going metabolism book for revision or as a good reference guide, this would be the ideal choice, as it is not too daunting to read and had plenty of well-organised pathway maps to keep you busy. This is especially useful for first year medics as part of their foundation study revision"
Leech y Gelen, University of Wales College of Medicine"
"The book is easy to follow as the salient features of each metabolic pathway are highlighted on a detailed background map. This aided the introduction of the metabolic concepts in a very well-integrated fashion. The chapters on the more medical aspects will appeal especially to medical students as they correlate neatly the basic biochemical principles with the development of some metabolic diseases such as glycogen storage diseases."
Biochemistry and Molecular Biology Education
